Abstract
Angina pectoris (AP) with coronary heart disease (CHD) is one of the common cardiovascular diseases in clinical practice, which can be classified as “chest paralysis” in Chinese medicine according to its symptoms, and it is described in many ancient documents. Ancient Chinese medicine believes that the main pathogenesis of the disease is poor blood flow leading to paralysis of the heart and veins, so it is often treated by activating blood and removing blood stasis. In this study, 120 patients with AP of CHD of Qi stagnation and blood stasis type were randomly divided into the observation (n = 60) and the control group (n = 60). In the control group, basic care, conventional treatment, and unselected copper acupuncture scraping were used, while in the observation group, copper acupuncture scraping was performed at the right time of the heart meridian (11 : 00–13 : 00) on the basis of the control group, and all patients received the treatment for a total duration of 4 weeks. We collected data on the traditional Chinese medical (TCM) syndrome score, frequency and duration of angina attacks, nitroglycerin dosage, inflammatory factor levels, and hematological indices pretreatment and posttreatment in both groups. Patients' adverse effects during treatment were recorded, and the clinical efficacy and ECG efficacy in both groups were evaluated after 4 weeks. We used SPSS.20 statistical software to statistically analyze the above data, and the results showed that the clinical efficacy and ECG efficacy of the observation group were significantly higher than the control group posttreatment. After treatment, the TCM symptom score, angina attack frequency, attack duration and nitroglycerin dosage, serum interleukin-8 (IL-8), hypersensitive C-reactive protein (hs-CRP), and tumor necrosis factor-α (TNF-α) levels, whole blood viscosity (WBV), plasma viscosity (PV), fibrinogen (FIB), and hematocrit (Hct) were significantly lower in both groups compared with those posttreatment. And the observation group showed a greater decrease when compared with the control group. The results also showed that the overall incidence of adverse reactions was lower in both groups during the treatment period. The above results indicate that while ensuring high safety, the copper stone based on theory of midnight-noon ebb-flow can more effectively improve the symptoms and inflammatory response of the body and reduce the viscosity of the blood in AP with CHD of Qi stagnation and blood stasis, and it has better therapeutic effects.
Highlights
coronary heart disease (CHD) with Angina pectoris (AP) belongs to the category of “thoracic obstruction” in traditional Chinese medicine (TCM), which has been described in many works, and TCM has a long history of efficacy in the prevention and treatment of this disease [4, 5]. e theory of midnight-noon ebb-flow originated from Huangdi’s Classic on Medicine, which is guided by the idea of “nature-human integration” and believes that the strength of human Qi and blood corresponds to the natural circadian rhythm [6]
59 patients in the control group and 56 patients in the observation group completed the full course of treatment. e results of the efficacy analysis showed that the difference in total clinical efficiency between the two groups was statistically significant (P < 0.05, Figure 1)
tumor necrosis factor-α (TNF-α) is an important mediator of the inflammatory response and has a promotional significance for coagulation. hypersensitive C-reactive protein (hs-CRP) belongs to the acute temporal phase proteins and is a sensitive indicator of inflammation in the organism [20, 21]. e results of this study showed that the levels of IL-8, hs-CRP, and TNF-α were lower in the observer group than in the control group after treatment, suggesting that Gua Sha with copper stone based on the theory of midnight-noon ebb-flow may reduce the risk of cardiovascular events by reducing the inflammatory response. e reason for this analysis may be the direct stimulation of the skin by Gua Sha, which activates vascular and lymphatic circulation, improves blood perfusion, enhances intracellular metabolism, and promotes repair of damaged tissues [22]
Summary
Angina pectoris (AP) with coronary heart disease (CHD) is a series of chest pain syndromes caused by atherosclerosis of the patient’s coronary arteries, resulting in myocardial ischemia and hypoxia, with symptoms manifesting as recurrent episodes of crushing pain at the posterior sternal location, and is a common clinical cardiovascular disease [1, 2]. e incidence of CHD is quite high in the Chinese population, and modern medicine regarding the treatment of CHD is still based on multifaceted comprehensive treatment, which includes conservative medical drugs, PCI and CABG [3]. e recurrence rate of CHD with AP remains high despite the many approaches available, so it is urgent and necessary to actively search for new effective drugs and treatments. Modern medicine believes that Gua Sha therapy has antiinflammatory, antioxidant, immune enhancement, microcirculation improving, and neuromodulation stimulating effects on the human body [7, 8]. E Gua Sha therapy based on the theory of midnight-noon ebb-flow is in accordance with the relationship between the meridians of the human body and the twelve two-hour periods of the day, the selected meridians are scraped during specific times, and the combination of points, lines, and surfaces can effectively stimulate multiple areas at the same time. E patients with Qi stagnation and blood stasis (chronic stable AP) were selected as the subjects of this study and treated with scraping with copper stone base on the theory of midnight-noon ebb-flow and achieved good efficacy We have been treating patients with AP of CHD for many years and have accumulated rich clinical experience by using TCM methods such as Gua Sha and foot baths. e patients with Qi stagnation and blood stasis (chronic stable AP) were selected as the subjects of this study and treated with scraping with copper stone base on the theory of midnight-noon ebb-flow and achieved good efficacy
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