Study of Safety of Molybdenum and Iron-Molybdenum Nanoclaster Polyoxometalates Intended for Targeted Delivery of Drugs

Alexander A Ostroushko,Irina G Danilova,Maria V Morozova,Margarita O Tonkushina,Anna V Prokofieva,Svetlana Yu Medvedeva,Irina F Gette

doi:10.4236/jbnb.2011.225066

Alexander A Ostroushko, Irina G Danilova + Show 5 more

Open Access

https://doi.org/10.4236/jbnb.2011.225066

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Abstract

Nanocluster polyoxometalates with a structure of buckyball (fullerene) are a promising means of targeted delivery of drugs in the body. In this paper, based on an analysis of histological sections of liver and kidney and peripheral blood, showed a significant reduction of toxicity of buckyballs, containing ions of molybdenum (VI), the substitution of Mo (V) ions to Fe (III), in contrast to buckyballs based on Mo (V). The absence of accumulation of molybdenum in rats with a daily intramuscular injection of aqueous solutions of both drugs within a month was confirmed.

Highlights

The search for effective and safe means of targeted delivery of drugs is one of the most pressing issues of nanobiotechnological studies [1,2,3]
In this paper, based on an analysis of histological sections of liver and kidney and peripheral blood, showed a significant reduction of toxicity of buckyballs, containing ions of molybdenum (VI), the substitution of Mo (V) ions to Fe (III), in contrast to buckyballs based on Mo (V)
Exchange of buckyballs based on molybdenum and iron may be different from the usual exchange of compounds of these elements in the body due to the unique features of nanoflakes, so it is necessary to study the toxicity of buckyballs

Summary

Introduction

The search for effective and safe means of targeted delivery of drugs is one of the most pressing issues of nanobiotechnological studies [1,2,3]. These compounds (Мо132) consist of coordination oxygen polyhedra surrounding ions of molybdenum, as well as stabilizing ligands (acetate ion, etc.), water molecules. A related compound is an iron-molybdenum buckyball Mo72Fe30 [5] (2), in which Mo(V) ions are replaced by Fe(III). Study of Safety of Molybdenum and Iron-Molybdenum Nanoclaster Polyoxometalates Intended for Targeted Delivery of Drugs tines and does not accumulate in the body. Exchange of buckyballs based on molybdenum and iron may be different from the usual exchange of compounds of these elements in the body due to the unique features of nanoflakes, so it is necessary to study the toxicity of buckyballs. The purpose of this study: the study of toxicity of buckyballs based on molybdenum and iron, designed as containers or cores for transport of drugs

Materials and Methods

Results and Discussion

Conclusions