Study of risk factors for development of urinary bladder cancer in patients in Urmia; a single-center study by logit regression approach

Rasool Gharaaghaji,Yasamin Pouladi,Ali Tehranchi

doi:10.15171/jrip.2019.56

Rasool Gharaaghaji, Yasamin Pouladi + Show 1 more

Open Access

https://doi.org/10.15171/jrip.2019.56

Copy DOI

Abstract

Introduction: Urinary bladder cancer is the most common genitourinary system malignancy in humans. Objectives: Due to the high prevalence of urinary bladder cancer, having enough knowledge about urinary bladder cancer risk factors can assist in prevention and early recognition of this malignancy. Patients and Methods: In this study case-control, 109 individuals with urinary bladder tumor (as a case group) and 200 individuals without any neoplastic history aged >40 years (as a control group) were included (2016-2017). The data were collected using patients’ files, their pathology reports and also a checklist. The data were analyzed using SPSS version 20, and logistic regression test was applied to investigate the binary outcome. A P value less than 0.05 was considered significant. Results: The results showed, a significant relationship between smoking (P<0.001), having high risk occupation (P<0.001), low water intake (P<0.001) and pickle consumption (P<0.001) with urinary bladder cancer. Conclusion: Smoking is a strong risk factor for urinary bladder cancer. Our study showed smoking and other occupational carcinogens are the main causes of urinary bladder cancers. Thus preventing and controlling these risk factors are important for health schedules.

Highlights

Urinary bladder cancer is the most common genitourinary system malignancy in humans
Implication for health policy/practice/research/medical education: According to the results of our study, it seems that the risk factors of cigarette smoking, male gender, high-risk occupation, the use of pickles and low-intake of water are associated with urinary bladder cancer
Studies on the effects of risk factors such as nutrition, fluid intake, body mass index (BMI), and diabetes on bladder cancer are few and most of the studies are about the effects of cigarette smoking, drugs and occupations on urinary bladder tumor

Summary

Introduction

Urinary bladder cancer is the most common genitourinary system malignancy in humans. Results: The results showed, a significant relationship between smoking (P < 0.001), having high risk occupation (P < 0.001), low water intake (P < 0.001) and pickle consumption (P < 0.001) with urinary bladder cancer. Conclusion: Smoking is a strong risk factor for urinary bladder cancer. Our study showed smoking and other occupational carcinogens are the main causes of urinary bladder cancers. The cause of urinary bladder cancer is not well-known, while multiple risk factors including tobacco use, occupational exposure to chemicals, schistosomiasis, drugs, urinary tract infection (UTI) and urinary bladder’s stones have been identified [4,5]. Men are 3-4 times likely to develop urinary bladder cancer than women which is probably due to the increased prevalence of smoking and exposure to environmental carcinogens [6].

Objectives

Methods

Results

Conclusion