Abstract
A Bakerbond ODS column was dynamically coated with the chiral selector N τ-n- decyl- l - histidine , and then loaded with copper(II) ions. A number of racemic mixtures of underivatized amino acids were resolved on such a column via chiral ligand-exchange chromatography. The most important experimental parameters influencing column efficiency, retention and selectivity (eluent flow-rate, analyte concentration, temperature and mobile phase composition) were extensively investigated. Results are discussed in light of CLEC theory and thermodynamic data on model systems in aqueous solution. The most likely structures for the stationary ternary complex are suggested.
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