Study of Relationship Between Umbilical Artery Lactate Level in Newborn, Ominous Non-Stress Test Fetal Heart Rate Patterns and Hypamnion Neonatal Outcomes

Abstract

Objective To study relations between umbilical artery lactate levels, ominous non-stress test (NST)fetal heart rate monitoring and newborn outcomes. Methods From February 2007 to February 2010, 140 cases hypamnion pregnant women(observation group) who was delivery with uterogestation and singleton fetus, and meanwhile 140 cases with normal amniotic fluid quantity were into control group. All the pregnant women took non-stress test monitoring 20-40 minutes 1-2 days before antepartum. Non-stress test monitoring graph, umbilical artery lactate level in newborn, and neonatal behavioral neurological assessment (NBNA) after birth were taken for each newborn. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Qingdao Central Hospital. Informed consent was obtained from all participants. Results The disappearance of non-stress test baseline variability and transient abnormal deceleration were very common in observation group, which could increase the cesarean section rate. The cord blood lactate levels in observation group was higher than that of control group with a significant difference (P<0.01). But the levels of cord blood pH and base excess (BE) in observation group were lower than those of control group (P<0.01). The umbilical cord blood lactate level and pH level, base excess level was negatively correlated. Conclusion The umbilical cord blood lactate level and pH level, base excess level have a good correlation. The disappearance of non-stress test baseline variability or transient abnormal deceleration were related with high cord blood lactate level and adverse outcomes in newborns. Key words: umbilical artery; lactate; fetal monitoring; hypamnion; newborn outcome