Abstract
Objective To evaluate the value of proton magnetic resonance spectrum (1H-MRS) in the differential diagnosis of Alzheimer's disease (AD) and vascular dementia (VD) patients with white matter lesions(WMLs). Methods Multi voxel 1H-MRS were performed to 30 patients with AD, 30 patients with VD, and 30 normal control volunteers. The levels of the N-acetylaspartate (NAA), myo-inositol (mI), glutamate (Glu), and creatine (Cr) were measured in the white matter adjacent to the lateral ventricles. The ratios of NAA/Cr, mI/Cr and Glu/Cr were calculated and compared among the group. Comparisons of the 1H-MRS indexes among AD, VD and NC group were conducted by one-way ANOVA. Results NAA/Cr ratios of the region of interesting in AD (1.59±0.15)and VD(1.53±0.12) group were significantly decreased compared with NC (1.79±0.22)group (P 0.05), and Glu/Cr ratios in AD and VD groups were significantly different (P 0.05). Conclusion Multi-voxel 1H-MRS is an effective method in the differential diagnosis of dementia, and changes of the mI/Cr and Glu/Cr ratios of the white matter adjacent to the lateral ventricles may help to identify the AD and VD patients. Key words: Alzheimer disease; Vascular dementia; White matter lesions; Magnetic resonance spectroscopy
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