Abstract
Introduction: System injury, manifested as metabolic dysfunction is a common side effect of chemotherapy. Chemical stress on hepatic and kidney cells can be evaluated by biochemical analysis, including serum aminotransferases, glutathione levels and extent of lipid peroxidation. Combined treatment of chemotherapy along with the natural products such as phytochemicals may be a newer approach to reduce the side effects and betterment of chemotherapy. Objective: The present study was conducted to assay kidney and liver associated parameters on animals exposed to etoposide, and the protective effect of different doses of Spondias pinnata bark extract on normal cells. In this study, total 24 male Wistar rats ( either sex) aged between 60 to 90 days were considered. Each group consisted of six rats. Levels of Alanine and Aspartate aminotransferases were estimated using semi-auto analyser and GSH, GST, TAO and LPx by spectrophotometry. Results and Conclusion: Data analyzed using Graph Pad 5.0. Variation in the analyzed parameters were found between control, chemotherapy and Spondias pinnata groups. Results of the study show that significant increase in TBARS levels indicative of etoposide induced oxidative stress could be prevented by treatment with S. pinnata. GST levels also support the preventive action of S. pinnata against etoposide induced stress. However, TAO and transaminases remain unaltered in the study groups
Highlights
System injury, manifested as metabolic dysfunction is a common side effect of chemotherapy
In this study we evaluated the effects of S. pinnata bark extract, chemotherapeutic agent etoposide and the effect of bark extract on liver and kidney after the administration of etoposide by estimation of LPx, GSH and total antioxidant activity
Treatment with S. pinnata bark extract after chemotherapy showed a significant increase (p
Summary
System injury, manifested as metabolic dysfunction is a common side effect of chemotherapy. Results of the study show that significant increase in TBARS levels indicative of etoposide induced oxidative stress could be prevented by treatment with S. pinnata. GST levels s upport the preventive action of S. pinnata against etoposide induced stress. Most of the anticancer drugs have side effects on human normal cells when they are used to treat tumor cells.[4] Etoposide has been recognized as active compound used potentially for treatment of various cancers. This compound can be used for further research due to its bio-molecular mechanisms that target cancer cell proliferation. Along with the cancer drugs supportive medication is needed to reduce above mentioned toxic effects on normal cells
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