Study of Procalcitonin Level in Obese Prevalent Hemodialysis Patients and Its Relation to Hemodialysis Adequacy

Abstract

Abstract Introduction In hemodialysis (HD) patients procalcitonin considered as an early predictor of acute infection. It represents a new and potential marker of inflammation and may correlate with dialysis adequacy. This makes procalcitonin a potential biomarker for obesity-related low-grade inflammation. Objective To assess procalcitonin level in obese prevalent hemodialysis patients and its relation to hemodialysis adequacy Methods A cross sectional study was conducted on 90 patients divided into 3 groups, 40 obese (BMI ≥ 30 Kg/m2) ESRD patients on regular hemodialysis at dialysis unit of El-Sahel Teaching Hospital (group A), 40 non obese (BMI < 25 Kg/m2) ESRD patients on regular hemodialysis (group B) and 10 healthy individuals with BMI < 25 Kg/m2 as a control group (group C).All patients were subjected to detailed history taking and general examination. All patients were laboratory investigated for CBC, serum urea, creatinine, CRP, Urea reduction ratio (URR), equilibrated Kt/v. All controls were subjected to written informed consent, full history and examination and CRP level. Procalcitonin level was done by ELISA technique for all patients and control. Results In our study, we found that there was a higher level of procalcitonin (PCT) in obese hemodialysis patient than non-obese. We also found that there was no correlation between PCT and hemodialysis adequacy in our study population. Conclusion Our study showed that procalcitonin is a potential biomarker for obesity-related low-grade inflammation. But not related to hemodialysis adequacy.