Abstract
Background: This study aimed to evaluate the results of prenatal screening and diagnosis for Down, Edward and Patau syndrome in the central of Vietnam. Materials and method: First trimester screening using combined serum marker test (free β-HCG, PAPP-A) including nuchal translucency by the FMF software. The high risk pregnancies was tested by QF-PCR diagnosis using amniotic fluid. Results: Screening for 1516 pregnancies, 145 pregnancies at high risk for Down, Edward and Patau syndrome. However, there was only 78 of them agreed to participate in diagnostic amniocentesis. Found 7 cases of abnormal number of chromosomes. Conclusion: The rate of high-risk pregnancies was 9.6%. Percentage of pregnancy with high-risk diagnostic agreement was 53.8%. The rate of abnormal number of chromosomes was 9.0%, in which 85.7% of T21, 14.3% of T18, did not find any cases of T13 detected by QF-PCR technique.
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