Study of Platinum Nanoparticles with Methotrexate as Drug Delivery System for Cancer Therapy on MCF7

Abstract

The present study aims to innovative nanotechnology that can overcome multidrug resistance (MDR), raise drug localization, and efficiency. This is done by applying a nanotechnology technique to cancer cells, which lead up to a new prospect for developing treatment methods on cancer cells. Platinum nanoparticles (PtNPs) was synthesized by the chemical approach in a range of different temperatures (180- 200-220-240-260°C), the characteristics of Pt NPs were measured using atomic force microscopy (AFM), UV-visible spectroscopy, zeta potential and dynamic light scattering (DLS). The cytotoxicity of Pt NPs was tested in vitro by applying it on MCF7 cell lines first as an anticancer agent, second as a drug delivery system by combining the nanoparticle with Methotrexate together, and third as an applied Methotrexate alone on cell lines. The effect of Pt NPs and Methotrexate was measured by MCF7 assay to evaluate their drug delivery activity and anticancer activity. The result of the MCF7 assay test shows a great potential of Pt NPs with a high inhibition rate of cancer cell growth. How to cite this article: Al-Karam, L.Q. and Al-Neami A.Q., (2019). Study of Platinum Nanoparticles with Methotrexate as Drug Delivery System for Cancer Therapy on MCF7. International Journal of Drug Delivery Technology, 9(4): 575-579. Source of support: Nil. Conflict of interest: None.