Abstract
The current study focuses on the synthesis and the biological evaluation of Schiff base metal complex produced from the diuretic drug Hydrochlorothiazide. The bidentate ligand is produced by inserting salicylaldehyde into a 1:1 molar ratio and condensing 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine -7-sulfonamide. Complex of Co(II) with general formula ML2 have been produced using this bidentate ligand. We examined the antibacterial properties of the produced compounds. The results that were achieved were compared with the original medicine, hydrochlorothiazide. The compounds exhibited enhanced antibacterial assay, with the Co(II) complex demonstrating especially strong activity. The ligand and its complex Co(II) were also screened for the invivo Diuretic techniques.
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