Study of pharmacodynamics of triazoline compounds in quail growing

Abstract

When new compounds of the triazoline series are introduced into the diet, it contributes to the preservation of livestock, increases weight gain and improves metabolic processes in the metabolism of quails. The purpose of our research was to study the pharmacotoxicological properties and to substantiate the effectiveness of the use of the compound of the triazoline series GKPF-109 in poultry farming. The study was conducted in the period from 2022 to 2023 at the Odesa State Agrarian University. To conduct an experiment to study the pharmacodynamics of the compound of the triazoline series GKPF-109, day-old quails of the Pharaoh breed, clinically healthy, were selected and divided into four groups of 30 heads in each: 1 control group, which was not given a compound of the triazoline series; 2 experimental group drank the compound of the triazoline series GKPF-109 - 0.5% solution; in experimental groups Nos. 3 and 4, the compound of the triazoline series GKPF-109 –1.0% and 1.5% was administered, respectively. Research methods were used during the work: morphological and biochemical, statistical.The results showed that the pharmacodynamic effects of the compound of the triazoline series GKPF-109 when included in the diet of quails in doses from 0.5 to 1.5% contribute to: increasing the preservation of poultry stock by 6.7–13.4%; growth-stimulating effect when increasing body weight gains by 3.7-9.1%; an optimizing effect on erythro- and hematopoiesis with an increase in the concentration of erythrocytes by 9.5–10.8% and hemoglobin by 5.1–6.3%; improvement of metabolic indicators, an increase in the level of total protein by 3.3–6.9%, albumin by 9.1–14.5%, glucose by 8.2–9.3%, and calcium by 5.8–6.6%. The use of the compound of the triazoline series GKPF-109 contributes to the reduction in the blood of lipid peroxidation products and the level of endogenous intoxication while improving the condition of the liver of quails. Analyzing the above, it can be concluded that adding a 1% solution of the compound of the triazoline series GKPF-109 to drinking water is the most pharmacologically effective and economically feasible in raising quail