Abstract
The antifungal variant from Taxus callus has been screened. The accumulation of biomass and paclitaxel of resistant and wild-type cells on modified MS medium or treated by fungal-elicitor was compared. The results showed that the production of biomass and paclitaxel of resistant cells was approximate as that of the wild-type cells on normal modified MS medium, but it was 70-fold higher when stimulated by fungal-elicitor. And there were evident difference on the activity of peroxidase (POD), phenylalanine ammonialyase (PAL) and the content of superoxide anion (O2 −) between the antifungal variant and wild-type cells. The results implied that the intensity and velocity of the occurrence of secondary metabolism of antifungal variant were higher than those of the wild-type cells and the selection of resistant variant will be a good new path to improve paclitaxel production.
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