Study of Oxidative Stress Status in Relation to Glycemic Index Fluctuations in Type II Diabetes Mellitus Patients

Abstract

ABSTRACT Background Oxidative stress is characterized by an increased generation of O2-derived molecules called reactive oxygen species that provoke critical, even irreversible, cell injury. Aim To evaluate oxidative stress status through measurement of malondialdehyde (MDA) and to analyze association of changes in MDA status with respect to fluctuations in glycemic control. Materials and methods A total of 112 subjects, both males and females, aged above 30 years were enrolled for this study, in which 81 had type II diabetes and 31 were without diabetes. Random blood sugar (RBS) was measured by glucose oxidase and peroxidase method. Serum MDA was measured by thiobarbituric acid reactive substances method. Glycated hemoglobin (HbA1c) was measured by ion exchange resin method. Results The MDA and HbA1c levels were increased in diabetics and were statistically significant. In all the studied groups, MDA was positively correlated with RBS and HbA1c. Conclusion and clinical significance The study suggests that MDA should be measured along with routine parameters of disease and the use of redox active antioxidants to tone down MDA levels may be evaluated to contribute in early and improvised clinical management of type II diabetes mellitus and also to delay the development of secondary complications of the disease. How to cite this article Arafeen S, Chatterjee M. Study of Oxidative Stress Status in Relation to Glycemic Index Fluctuations in Type II Diabetes Mellitus Patients. Indian J Med Biochem 2017;21(1):49-53.