Study of ovarian reserve markers as predictors of in vitro fertilization-embryo transfer outcome in increased-basic follicle stimulating hormone population

Abstract

Objective To explore the predictive value of ovarian reserve markers for people with increased basic follicle stimulating hormone (bFSH) levels in in vitro fertilization (IVF) outcomes. Methods A retrospective analysis of 545 cycles of patients with bFSH≥10 IU/L receiving IVF/intracytoplasmic sperm injection-embryo transfer (ICSI-ET) treatment was performed. Patients in 171 cycles were 1.1 μg/L, respectively. Baseline data, cycle cancellation rate, clinical pregnancy rate, implantation rate and early abortion rate were compared among these 4 groups. Logistic regression analysis was performed to determine the correlation between ovarian reserve markers and cycle cancellation and clinical pregnancy. Results With the increase of age and AMH, IVF outcomes decreased in the high bFSH population, retrieved oocytes and available embryos decreased also. In low AMH groups (group A, group C), the cancellation rates of the IVF cycles (due to not get eggs and no oocyte retrieval and poor-quality embryo) (31.88%, 38.89%) were higher than those in high AMH groups (18.63%, P=0.046; 10.47%, P=0.001), the difference was significant; the clinical pregnancy rates (38.89%, 25.93%) were lower than those in high AMH groups (62.26%, 38.46%) with no significant differences (P>0.05); the early abortion rates (14.28%, 42.85%) were higher than those in high AMH group (6.10%, P=0.437; 0, P=0.027). It was found that bFSH value was positively related to whether the cycle was cancel, while the antral follicle count (AFC) was negatively related to whether the cycle was cancel. Only the age was negatively related to the clinical pregnancy rate of IVF fresh cycle. Conclusion The age and AMH level are factors affecting IVF outcomes in patients with high level of FSH, which can be used to guide the clinical practice. Joint of AFC and bFSH to cycle cancellation, and age to fresh transplant clinical pregnancy have good prediction effects. Key words: In vitro fertilization and embryo transfer (IVF-ET); Anti-Mullerian hormone (AMH); Basic follicle stimulating hormone (bFSH); Antral follicle count (AFC); Age; Pregnancy outcome