Abstract
The optical isomer separation of chiral antifungal drugs tetramisole, miconazole, and paclobutrazol on Pirkle‐type (S,S)‐Whelk O1 chiral column in three‐component normal phase mode was described. When the polar modifier in hexane mobile phase was iso‐propanol, ethanol, and n‐butanol, respectively, the chiral separation of each solute was investigated. Then on self‐prepared cellulose tris (3,5‐dimethylphenylcarbamate) (CDMPC) chiral column, comparative study of chiral separation was made, to discuss the different chiral recognition mechanisms between the solutes and the two different types of chiral stationary phases. We thank Prof. Dr. Kinkel in Georg‐Simon‐Ohm University of Applied Science (Nürnberg, Germany) for providing (S,S)‐Whelk‐O1 chiral column.
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