Abstract
AbstractPhosphorylation is a posttranslational modification used to regulate the functions of a variety of proteins, including neurotransmitter receptors. Protein phosphorylation is catalyzed by protein kinases transferring a phosphate molecule from ATP to a protein substrate. The addition of the negatively charged phosphate group alters the structure of the protein and regulates its functional properties. Protein phosphorylation is a highly regulated reversible process and thus the level of receptor phosphorylation in neurons is constantly modified by neurotransmitters and other cellular signals released by surrounding neurons. KeywordsOpioid ReceptorChinese Hamster Ovary CellOkadaic AcidReceptor DesensitizationReceptor PhosphorylationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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