Abstract
This study characterized the synthetic Zn(II)Prolinedithiocarbamate and determined its anti-cancer activity in vitro and in silico. Zn(II)Prolineditiocarbamate complex was synthesized, characterized, and determined by melting point, conductivity value, UV–Vis spectroscopy, FT-IR and XRD. Computational NMR spectrum analysis has been carried out. Zn(II)Prolinedithiocarbamate complex's binding to DNA was studied using an in vitro molecular docking anti-cancer activity assay. Molecular docking results showed the interaction of Zn(II)Prolinedithiocarbamate complex with DNA from MCF-7 strain cells. Cytotoxicity of Zn(II)Prolinethiocarbamate against the MCF-7 cell line showed changes in cancer cell morphology at an IC50 value of 360.10 g/mL. Zn(II)Prolinedithiocarbamate complex compounds can be a breakthrough in developing chemotherapy drugs that are potential and effective against the MCF-7 cell line.
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