Abstract
This study characterized the synthetic Zn(II)Prolinedithiocarbamate and determined its anti-cancer activity in vitro and in silico. Zn(II)Prolineditiocarbamate complex was synthesized, characterized, and determined by melting point, conductivity value, UV–Vis spectroscopy, FT-IR and XRD. Computational NMR spectrum analysis has been carried out. Zn(II)Prolinedithiocarbamate complex's binding to DNA was studied using an in vitro molecular docking anti-cancer activity assay. Molecular docking results showed the interaction of Zn(II)Prolinedithiocarbamate complex with DNA from MCF-7 strain cells. Cytotoxicity of Zn(II)Prolinethiocarbamate against the MCF-7 cell line showed changes in cancer cell morphology at an IC50 value of 360.10 g/mL. Zn(II)Prolinedithiocarbamate complex compounds can be a breakthrough in developing chemotherapy drugs that are potential and effective against the MCF-7 cell line.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.