Abstract
In our continuous effort toward synthesis of potential bioactive agents, two series of benzonitriles/nicotinonitriles endowed with β-lactams bound to s-triazine skeleton were synthesized by applying an efficient palladium catalyzed C–C Suzuki coupling reaction. The synthesized compounds were screened for their in vitro antimicrobial against different human pathogenic microorganisms and prostate cancer PC3 cells. Some compounds displayed remarkable antimicrobial activity and noticeable anticancer activity. It was observed that both benzonitrile and nicotinonitrile sets are essential to increase the different pharmacological activities. The new synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, and MS analysis.
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