Abstract

Abstract: Before the twentieth century, drugs used for the treatment of diseases were obtained from natural sources like plants, animals, microorganisms, and minerals, and among them, plants were the major source of natural drugs. At present, most of the drugs are obtained from synthetic and biosynthetic sources. The nature was once served as the source of all medicaments and plants, especially the higher plants have been continuing the service since antiquity as important sources of novel compounds useful directly as medicinal agents, as model compounds for synthetic or semi-synthetic structure modifications and optimization, as biochemical and/or pharmacological probes, and as sources of inspiration for generations of synthetic organic medicinal chemists. Plant-derived compounds which have recently under- gone development include the anti-cancer agents, taxol and camptothecin, the Chinese antimalarial drug, artemisinin, and the East Indian Ayurvedic drug, for-skolin. These and many other examples serve to illustrate the continuing value of plant-derived secondary metabolites as viable compounds for modern drug devel- opment (Newman et al. 2003; Newman and Cragg 2007). Natural sources are most primitive and abundant. Drugs obtained from the natural sources include a. Plant, b. Animal, c. Microbial, d. Marine, e. Mineral, and f. Geographical sources. Plant, Animal, Microbial and Marine may be put under common heads—the biological sources.

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