Abstract
Natural extracellular matrices (ECMs) perform the tasks necessary for tissue formation, maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials. In addition, biomedical materials have claimed attention because of the increased interest in tissue engineering materials for wound care and regenerative medicine. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this work, we present the extracellular matrix (ECM) using the bacterial cellulose (Nanoskin®) which regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. Bacterial cellulose fermentation process is modified before the bacteria are inoculated for mimicking ECM to cells support and built new local material for wound healing. Chemical groups influences and thermal behavior in bacterial cellulose were analyzed using transmission infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), respectively. Besides, In vivo analysis was evaluated with clinical study at Sharjah Kuwait Hospital.
Highlights
Tissue engineering is a recent field that creates functioning artificial tissues and organs
Many strategies use an artificial scaffold that functions as the extracellular matrices (ECMs) to facilitate both organization and differentiation of implanted cells into a functional 3D tissue [1]
Vegetal stem cells were obtained from Brazillian environment, Waltheria Douradinha
Summary
Tissue engineering is a recent field that creates functioning artificial tissues and organs. Many strategies use an artificial scaffold that functions as the ECM to facilitate both organization and differentiation of implanted cells into a functional 3D tissue [1]. Wounds are injuries that result in an ulcer or break of the skin. Healing is a complex process in response to an injury to restores the integrity of wound. Wound healing involves cell-cell and cell matrix interactions to allow the process [2] [3]. Wounds are followed by inflammatory processes with various mediators, such as eicosanoids, prostaglandins or cytokines [4]. To avoid inflammatory action, inhibition of NF-B activation is crucial to treat wounds inflammation [4]
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