Abstract
The aim of the study was to investigate the influence of low heating temperatures with two different retention times to optimize the process for obtaining nanosized hydroxyapatite material that can possibly be used in the fields of biology and pharmacy. Nanosized hydroxyapatite was successfully obtained by wet chemical precipitation. The annealing of the material performed at 300 oC with two different retention times i.e. 3 and 6 hours in air atmosphere. Low annealing temperature with extended retention time was selected in terms to reduce energy consumption. FTIR spectroscopy was used to confirm characteristic vibrational bands of hydroxyapatite samples, and presence of carbonate bands of hydroxyapatite annealed for 3h and 6h. X-Ray powder diffraction analysis were used to examine phase composition, determine the size of unit cells and crystallite sizes, and SEM-EDS methods were used to obtain particle size and arrangement also grain growth morphology and confirmed the presence of calcium, phosphorous oxygen and carbonate peaks. The results show that different retention time has influence on particle growth as well as unit cell parameters and crystallite sizes changes of hydroxyapatite material
Highlights
Hydroxyapatite (Ca5(PO4)3OH) is the principal inorganic component of natural bone and teeth
There is a lot of scientific studies where the effect of synthesis parameters and calcination temperature on the size, phase composition, and morphology of hydroxyapatite was studied, and similar results were obtained like in our study [1, 19,20,21,22,23,24,25] so we wanted to use a temperature slightly higher than the drying temperature and to monitor the changes over time of three and six hours which we considered to be the most optimal in terms of sample preparation
It is important to note that the synthesized materials by precipitation method may have a trace of the second phase, which occurred during the precipitation and it is in consistency with applied method
Summary
Hydroxyapatite (Ca5(PO4)3OH) is the principal inorganic component of natural bone and teeth Since it possesses excellent biocompatibility, high-bioactivity, non-toxicity and non-inflammatory properties, this material can be used as a potential biomaterial for hard tissue replacement [1,2,3,4,5]. Comparing to the above mentioned methods, direct precipitation from aqueous solution method is simpler way for preparing hydroxyapatite powders and provides the best yield [10, 11]. Advantages of this method include simple equipment, low cost and ability to obtain hydroxyapatite material with large quantity and high purity [1]. Using solution-precipitation technique for processing hydroxyapatite ceramic materials and low temperatures with optimal retention time is
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