Study of mordenite natural zeolite type modified by Cu(II) cation as an oral safe drug carrier for ibuprofen and meloxicam

Abstract

This research focused on the purification of mordenite (Mor) from the natural zeolite. Mor was then modified with Cu(II) to produce a new oral safe drug delivery material Cu(II)-Mor based on natural zeolite. Drug loading testing on Cu(II)-Mor used ibuprofen and meloxicam as drug models. The drug carrier and loading materials were characterized by using FTIR, XRD and FESEM-EDS. To use Cu(II)-Mor material as a drug carrier, in addition to the drug loading capacity factor, other factors such as drug release and zeta potential and cytotoxicity of drug delivery material were also investigated. The release of meloxicam from Cu(II)-Mor experienced the highest release at 1200 min in pH 7 with a dissolution percentage of 93.17%. The release of Ibuprofen from Cu(II)-Mor occurred at 1200 min in pH 7 with a dissolution percentage of 90.98 %. All release Ibuprofen and meloxicam were studied using six kinetics modeling: zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell and Korsmeyer-Peppas models. Based on kinetics modeling, ibuprofen and meloxicam release from Cu(II)-Mor followed Peppas–Sahlin model, indicating that Fickian diffusion and Case II relaxations dominate the drug transport mechanism from mordenite. The results showed that this drug carrier material has good cytocompatibility, drug loading and drug release. The results of the zeta potential test also show that the drug carrier material has high stability in the dispersion system. Overall, Cu(II)-Mor can be used as an oral safe drug material.