Study of mineral profile in patients with hypothyroidism

Abstract

Background: Thyroid hormones play important role in hemodynamic, thermoregulation and metabolism of the body. As a result, renal hemodynamic, glomerular filtration and electrolyte management may be affected in thyroid related problems. Thyroid disease particularly hypothyroidism has recently received more attention because it may be the primary cause of mineral metabolism disturbance due to its direct effect on bone turnover. Objective: To estimate the serum level of minerals (Calcium, magnesium, phosphorus, iron, zinc and selenium) in hypothyroid patients and compare them with normal healthy controls. Material and Methods: The study was carried out from January 2021 to December 2021 in 60 hypothyroid patients and 60 healthy controls (age group 20-60 years), attending the medicine OPD of Teerthanker Mahaveer College & Research Center, Moradabad, Uttar Pradesh. Serum minerals and thyroid profile were measured by using the automated method and their levels were compared with healthy individuals as controls. Results: The serum magnesium and phosphorus levels were significantly elevated whereas the levels of calcium and zinc were significantly decreased in hypothyroid patients compared to healthy subjects. However, iron (p=0.09) and selenium (p=0.38) levels in hypothyroid patients were found to be less than that of healthy individuals but the difference between them was not statistically significant. Conclusion: This study concludes that hypothyroid patients should have their serum mineral levels checked regularly, as early diagnosis and intervention can help to avoid further thyroid problems. It will be beneficial in treating hypothyroidism as well.