Abstract

Study of Mifepristone and Misoprostol Vs Misoprostol alone in mid trimester termination of pregnancy in tertiary care hospital

Highlights

  • Mid trimester abortion is termination of pregnancy between 13-28 weeks gestation

  • The majority of abortions are performed in the first trimester, there is still a need for second trimester abortion because of delayed diagnosis of fetal anomalies, logistic and financial difficulties in obtaining abortion services, and failure to recognise an undesired pregnancy in first trimester, which all contribute to the continuing need for late abortions [2,3]

  • In 7 women the reason for termination was IUD, 5 in view of missed abortion and 4 in view of unwanted pregnancy i.e. they had conceived during lactational amenorrhoea, 84% of the cases aborted by 9 hours in the study group against only 8% in the misoprostol alone group

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Summary

Introduction

Mid trimester abortion is termination of pregnancy between 13-28 weeks gestation. Indian MTP law (Medical Termination of pregnancy law, 1972) permits abortion till 20 weeks period of gestation by a registered medical practitioner provided all pre-requisites are met [1]. the majority of abortions are performed in the first trimester, there is still a need for second trimester abortion because of delayed diagnosis of fetal anomalies, logistic and financial difficulties in obtaining abortion services, and failure to recognise an undesired pregnancy in first trimester, which all contribute to the continuing need for late abortions [2,3]. Objective: The present study was conducted with an aim toassess and comparatively evaluate the efficacy of Mifepristone with Misoprostol and Misoprostol alone for mid trimester termination of pregnancy. Methods and Material: A prospective study was conducted on 50 women who presented to us for termination of pregnancy in the mid trimester due to various reasons. These 50 women were divided into two groups of 25 each. Result: Mean induction abortion interval from insertion of the first Misoprostol tablet was significantly shorter in the Mifepristone pre-treated [mean duration7hours] group as compared to Misoprostol alone group [mean duration 18hours]. Conclusion: Pre-treatment with Mifepristone 24hr before intravaginal Misoprostol significantly improves induction abortion interval

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Conclusion

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