Study of MICS in Hemodialysis Patients and Its Relation with Serum Thyroid Hormones

Abstract

Background: Malnutrition-inflammation complex syndrome (MICS) is a frequent and serious problem in patients undergoing dialysis with estimated prevalence about 18–75%. The etiology is multifactorial. MICS is believed to be main cause of erythropoietin hyporesponsiveness, low free triiodothyronine (FT3) and increased mortality and hospitalization among the dialysis patients. Objective: To determine the prevalence of MICS and identify association between MICS and thyroid hormones. Patients and Methods: This was cross sectional study, which was conducted on 91 patients admitted at Hemodialysis Units of Zagazig University Hospitals and Fakous General Hospital. Blood samples had been obtained before the initiation of the HD session and after an 8 hours fasting, blood measurements included: Serum urea, creatinine, TSH, T3, FT3 and FT4. Results: This study showed that, prevalence of MICS was about 56%. There was statistically significant difference between patients had MICS and patients without MICS regarding age, and duration of hemodialysis. There was no statistically significant difference between patients had MICS and patients without MICS regarding T3, T4, TSH. There was statistically significant difference between patients had MICS and patients without MICS regarding serum creatinine. Conclusion: This study concluded high prevalence of malnutrition-inflammation complex syndrome on patients on dialysis. There was no association between MICS and thyroid hormones.