Study of microbiological activity of topical antibacterial agents for treatment of combat injuries

Abstract

The problems of combat injuries are determined by the issue of treatment of purulent complications, because wounds received during combat operations are usually infected, and the most serious complication of such wounds is the development of purulent infection. Objective — to study the features of the aerobic component of combat wounds, the sensitivity of causative agents of wound infection to antibacterial drugs, and the antimicrobial activity of individual drugs in relation to extensively resistant and polyresistant microbial agents in order to develop external therapy algorithms as part of the complex treatment of these injuries. Materials and methods. The data of microbiological studies of patients with combat wounds were used in the work. Results and discussion. Based on the results of monitoring causative agents of purulent­inflammatory complications of wound injuries, a range of leading types of microorganisms was revealed. The isolation of flora resistant to most antibiotics from wounds dictates the need to change the strategy of infection control with strengthening measures to prevent nosocomial transmission, which should be considered when prescribing antibiotic therapy. Conclusions. Based on the results of monitoring the causative agents of purulent-inflammatory complications of wound injuries, a range of leading types of microorganisms was revealed: K. pneumoniae, E. faecalis, S. haemolyticus, P. aeruginosa, E. coli. The dominant microorganisms (by isolation frequency) in the wound contents were: staphylococci (3.0—5.69 lg CFU/ml), enterobacteria (4.69—7.0 lg CFU/ml), enterococci (3.0—4.69 lg CFU/ml). In addition, aerobic bacilli (3.0—3.69 lg CFU/g) and pseudomonads (5.69—7.0 lg CFU/g) were determined in the wound contents, which did not have a dominant character.The use of a topical agent containing dioxidin can contribute to the improvement of the effectiveness of the local treatment of purulent wounds infected with strains of gram-negative bacteria, in particular E. coli, K. pneumoniae and P. aeruginosa, with poly and extensive resistance to antibiotics both in monocultures and in microbial associations, in particular with strains of S. aureus, including MRSA.