Abstract
Aims & Objectives: To measure Microalbuminuria and hs-CRP in obese and non-obese male hypertensive patients and control groups and to correlate their levels with various stages of hypertension and different grades of hypertensive retinal changes. Men have higher prevalence of hypertension (29.4%) than women (26.5%)[1] Materials & Methods: The study was conducted among 60 normotensive individuals and 60 hypertensive individuals over a period of 6 months on OPD basis. All individuals were males in the age group of 40-60 years. Blood samples were collected and estimation of plasma glucose, urea, creatinine, lipid profile, hs- CRP and Urinary microalbumin were done. Results: The mean value of microalbuminuria and hs- CRP were higher among obese hypertensives than obese controls and were statistically significant. The changes in the mean value of microalbuminuria and hs-CRP within the different stages of hypertension were highly significant. Similarly the correlation of microalbuminuria and hs-CRP within the different grades of hypertensive retinal changes were highly significant. Conclusion: The serum level of hs-CRP and urinary microalbuminuria were elevated in hypertensive patients. The increase of both hs- CRP and microalbuminuria were significantly higher in obese hypertensives than non-obese hypertensives. Microalbuminuria & hs CRP levels correlate with various grades of hypertensive retinal changes.
Highlights
Hypertension is a common health problem and well known risk factor for cardiovascular diseases
Hs-C-reactive protein (CRP) is strongly associated with obesity and obesity related diseases like insulin resistance, DM and hyperlipidemia.CRP is produced by cells in adipose tissue in response to inflammatory stimuli
The serum level of hs-CRP, an early marker of low grade systemic inflammation is significantly elevated in hypertensive group
Summary
Hypertension is a common health problem and well known risk factor for cardiovascular diseases. Being clinically silent, it affects multiple organs and organ systems like kidney, brain and heart. The increasing levels of blood pressure may promote endothelial expression of cytokines and stimulates pro-inflammatory response in the arterial wall; resulting in vascular end-organ damage. [3] Obese individuals produce inflammatory markers referred as adipocytokines secreted by the adipose tissue under the influence of pro-inflammatory cytokines.[4] The most common available inflammatory marker of vascular endothelial damage are hs-CRP and microalbumin. [6] Urinary albumin excretion is seen in a large proportion of essential hypertensive patients, reflecting early endothelial damage in vascular tree of the kidney. Microalbuminuria is a condition with low but abnormal amount of albumin in
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