Study of macular retinal thickness measured by three dimensional Optical Coherence Tomography (3D-OCT) for acute primary angle-closure glaucoma

Abstract

Objective To measure macular retinal thickness parameters in acute primary angle-closure glaucoma (APACG) patients and to compare them to normal subjects using three dimensional Optical Coherence Tomography (3D-OCT) and discuss the possible mechanism.Methods The prospective analysis included 26 participants with APACG affected 30 eyes (including 22 patients with unilateral affected eyes and 4 patients with bilateral eyes) and 40 healthy subjects in control group.3D-OCT was used to measure and compared the macular retinal thickness in both two groups' eyes.Results Comparison of the macular retinal thickness between the groups showed that the thickness in the APACG eyes were significantly greater than in healthy eyes at fovea and at lmm from the fovea (t =4.07,3.30; both P =0.00),while there were no statistic difference in macular inner-ring retinal thickness and outer-ring retinal thickness (both P ＞0.05).The retinal thickness at fovea and at lmm from the fovea in APACG eyes were (238.38±51.77)μm,(248.31±40.79)μm,while in healthy eyes were (195.73±16.38)μm,(220.15±-18.61)μm.Conclusions Macular retinal thickness in the APACG eyes is significantly greater than in healthy eyes at fovea and at lmm from the fovea,presumably because of macular edema.The innovation of OCT technology may probably help us to learn more about the pathogenesis of acute angle-closure glaucoma. Key words: Acute primary angle-closure glaucoma; Macular; Optical coherence tomography