Abstract
Vancomycin, immobilized on silica, served as the chiral stationary phase (CSP) in this investigation with a polar organic solvent as the mobile phase in high performance liquid chromatography (HPLC). Enantiomers of alkoxysubstituted esters of phenylcarbamic acid (local anaesthetic drugs) were examined in order to evaluate the enantiorecognition process. The chromatographic behavior was investigated in order to obtain a deeper insight into the enantiodiscrimination process. A variety of factors, including the nature and concentration of the ionic modifiers in the mobile phase were examined. Conditions for the enantioseparation of derivatives of phenylcarbamic acid were found. The interaction mechanism of the separations is discussed.
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