Abstract
Purpose of the study: Research of the clinical and diagnostic significance of determination of Lipocalin-2 associated with neutrophilic gelatinases (uNGAL) in the urine of children with urinary tract infection (UTI) and pyelonephritis. Materials and methods: We examined 30 children with acute pyelonephritis and UTI aged 1 to 16 years (average age 7.32 ± 4.52) including 26 girls and 4 boys. Verification of the diagnosis was conducted on the basis of clinical and laboratory data, medical history and instrumental examination of patients. All children were divided into 2 groups: 1st group—15 children with acute pyelonephritis, 2nd group—15 children with urinary tract infection. uNGAL was measured in the urine by enzyme-linked immunosorbent assay (EISA) (BioVendor Laboratoty Medicine). Results: It is found, that the urine level of NGAL depends on the damage degree of renal parenchyma. The correlation of medium strength was found between the excretion level of uNGAL during the acute period of pyelonephritis and the detection of renal scars according to the DMSA-nephroscintigraphy data. In the group of children with the acute pyelonephritis the direct correlation of medium strength was found between the excretion level of uNGAL/creatinine and leukocytosis value and also with the CRP blood level. Conclusion: The results allow us to recommend the determination of the excretion level of uNGAL/creatinine as an additional non-invasive marker for the early detection of renal parenchyma injury.
Highlights
In the recent years there has been an increase in the frequency of urinary system diseases in children, whose share in the structure of microbial inflammatory diseases of kidneys and urinary tract is up to 80%.The prevalence of infectious and inflammatory diseases of the urinary system in childhood in the Russian Federation is 18 cases per 1000 pediatric population [1] [2]
Purpose of the study: Research of the clinical and diagnostic significance of determination of Lipocalin-2 associated with neutrophilic gelatinases in the urine of children with urinary tract infection (UTI) and pyelonephritis
Materials and methods: We examined 30 children with acute pyelonephritis and UTI aged 1 to 16 years including 26 girls and 4 boys
Summary
In the recent years there has been an increase in the frequency of urinary system diseases in children, whose share in the structure of microbial inflammatory diseases of kidneys and urinary tract is up to 80%. The prevalence of infectious and inflammatory diseases of the urinary system in childhood in the Russian Federation is 18 cases per 1000 pediatric population [1] [2]. The debut of this group of diseases is often observed on the background of upper respiratory tract infections RTI, intestinal infections , vaccination or exposure. Diagnostics and treatment of UTI are very important [6] [7].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
