STUDY OF LIPID PROFILE IN HYPERTENSIVE DISORDERS OF PREGNANCY

Abstract

Introduction : Hypertensive disorders complicate 5-10% of all pregnancies. endothelial cell injury are important in the pathogenesis of preeclampsia. Serum lipids have a direct effect on endothelial function. Abnormal lipid metabolism has a basic role in the pathogenesis of the disease. So study of lipid profile may be of good predictive value in hypertensive disorders of pregnancy. Method: This was a longitudinal study, done in the dept of OBGY, GMERS Medical College, sola, Ahmedabad, from August 2020 to July 2022. 93 women in each group were studied. Outcome was measured by serum lipid level, severity of hypertension, mode of delivery, need for neonatal resuscitation, NICU admission. Result: Serum Total cholesterol ≥240 mg/dl was observed to be 38.7% in group A and 14 % in group B. In group A with normal lipid profile 97.5% had mild hypertension, 2.5% had severe hypertension while in hypertensive with abnormal lipid profile group 53.8% had mild hypertension and 46.2% had severe hypertension. Normal vaginal delivery observed 64.52% in group A and 79.57% in group B. In group A, 35.48% babies and in group B ,5.37% babies required resuscitative measures. NICU admission was needed by 27.95 % in group A and 5.37% in group B. Conclusion: Serum lipid levels in hypertensive disorders of pregnancy is an important parameter for prediction of adverse perinatal outcome. Hypertensive disorders of pregnancy with dyslipidemia are associated with adverse perinatal outcome as compare to hypertensive disorders of pregnancy without dyslipidemia.