Study of Lipid Profile in Chronic Kidney Disease in Pre-dialysis Patients

Abstract

Background: Chronic Kidney Disease (CKD) causes irreversible damage to renal tissue resulting in decreasedkidney function. It will affect the cardio-vascular system and leads to morbidity and mortality.Study of lipidprofile in chronic kidney disease in pre-dialysis patientsMethod: 150 CKD adult patients were studied and compared with 150 controlled group. Lipid profile was studiedafter a minimum 12 hour fasting. About 10 ml blood was collected from median cubital vein and centrifuged at5000 rpm for ten minutes then lipid profile was done by VITROS slidemethod. The obtained results in both groupswere noted and compared.Result: Biochemical parameters had significant p values (p<0.001) except serum sodium.Overall dyslipidemiawas present in 27 (18%) CKD and absent in 123 (82%) CKD patients out 150, 9 (6%) patients were in 3rd stage, 45(30%) were at stage-IV, 96 (64%) were at Vth stage. In correlation of lipid profile with GFR, TG, HDL and VLDLhad significant p value (p<0.001).Conclusion: Present pragmatic study proved that, dyslipidemia progress with CKD. Early monitoring of lipidprofile may help to control the progression of CKD and avoid morbidity and mortality of CKD patients.