Study of Lipid Parameters in Subclinical Hypothyroidism

Abstract

Introduction: The Diagnosis of subclinical hypothyroidism is mostly biochemical as most of the patients have aserum TSH above the normal and serum free and total T4 and T3 are normal. Due to recent increasing prevalenceof sub-clinical hypothyroidism and metabolic risk factors such as adverse cardiac function and hyperlipidemia, itrecommended the importance of screening by assessment of serum TSH.Aims: To assess the lipid profile in patients diagnosed with sub-clinical hypothyroidismMethods and Materials: This study is a hospital based cross sectional study and comprised a total of 96 subjectsperformed in Chalmeda Anandrao Institute of Medical Sciences. Patients presenting to OPD with vague complaintsof hypothyroidism are selected. They are screened for subclinical hypothyroidism by doing fasting TFT comprisingfreeT4, freeT3 and TSH and fasting lipid profile is also done for the patient. Laboratory analysis of blood urea,serum creatinine done.Results: A Total number of 96 patients were studied, majority of them were between age group of 46 to 55 years.The BMI distribution among SCH has no correlation to serum TSH levels.Prevalence of subclinical hypothyroidism is more common among women.TSH values range from minimum of 5.8 mIU/l to maximum of 25mIU/l.Hypercholesterolemia was found in 40.6% of patients. LDL was elevated in 42.7% of cases. Triglyceride waselevated in only 27.1%. HDL values were found to be normal in 66.7% of cases.Conclusion: Our study concludes that there are significant elevations in total cholesterol and serum LDL insubclinical hypothyroidism. There is no much significant changes in triglycerides and HDL levels.