Abstract
The liquid extract of antihypertensive herbs could reduce blood pressure equivalent to Hydrochlorothiazide 25 mg based on research conducted in “Hortus Medicus” clinic, Tawangmangu, Central Java, but parameters of herbal medicine taste, design, and packaging had the lowest scores. Transdermal patch was chosen as an alternative to resolve those problems. Polymers determined the effectiveness of the active substance release from the formula. Patch was formulated from combination of hydrophilic hydroxy methylcellulose (HPMC) and carboxymethylcellulose natrium (CMC-Na) polymer which would produce a fast release profile. The objective of this research was to study the kinetics models of total flavonoid release and to study the total number of flavonoids released from the antihypertensive herbs patch for 5 hours, as well as to determine the optimum formula for observing the weight, pH and loss on drying. Herbs were infused with distilled water at 90 ° C for 15 minutes, filtered then evaporated. Release kinetics model used a modified type-5 dissolution apparatus equipment with a cellophane membrane. The optimum proportion of HPMC and CMC-Na was 220:180 mg. Patch was dark brown, circle shaped, moist and flexible. It had pH value of 7.29 ± 0.09, folding endurance of >350, and thickness of 0.64 ± 0.05 mm. The average percentage of total flavonoids released from the matrix patch was 37.23% for 5 hours. The release kinetics followed the Higuchi kinetics model with a diffusion mechanism.
Highlights
Jamu is Indonesian’s herbal medicine which was a cultural heritage used by Indonesian people as a treatment for diseases
This study used antihypertensive herbal medicine because hypertension was a disease with a relatively high prevalence compared to other non-contagious diseases that was equal to 64.83% in Indonesia as especially in Central Java (Central Java Provincial Health Office, 2018)
Patch has circular shape because it was printed on a Petri disk (Figure 1)
Summary
Jamu is Indonesian’s herbal medicine which was a cultural heritage used by Indonesian people as a treatment for diseases. The Center for Research and Development of Medicinal Plants and Traditional Medicines (B2P2TOOT)has combined these 6 plants into antihypertensive herbs to treat hypertensive diseases. Antihypertensive herbs medicine was usually formulated into liquid and capsules. It has been tested in the process of scientific verification and was used for treatment at the “Saintifikasi Jamu Hortus Medicus” Clinic, Tawangmangu. The parameters of herbal medicine taste, design, Jurnal Farmasi Sains dan Komunitas, 2021 18(1), 7-14 and packaging in scientific assessment of antihypertensive herbs of Hortus Medicus Clinic in B2P2TOOT had the lowest score (Maryani et al, 2017)
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