Abstract
Introduction: Kajjalikodaya malahara, mentioned in the Rasatarangini text, is indicated in different types of wounds like chronic wounds and fistula in ano, which did not respond to other treatment modalities. So, this formulation was selected for the present study. Material and methods: The Kajjalikodaya malahara prepared as per reference -anagni (without fire) and also modified version- agni siddha (with fire) method and subjected for antimicrobial, acute dermal toxicity studies and also screened for wound healing efficacy in excision and incision wound healing models. Results: The trial drug prepared by both methods was found safe in an antimicrobial study and did not reveal any acute dermal toxic conditions. In excision and incision wound healing model showed better therapeutic efficacy. Conclusion: Both formulations were efficient in the wound healing model’s study. Compared to a modified version of the agni siddha test drug, classically prepared anagni siddha was better in therapeutic efficacy.
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