Study of Intraocular Pressure Changes After Cataract Surgery with Topical Prednisolone Acetate 1% versus Topical Difluprednate 0.05%

Abstract

Introduction: Topical corticosteroids are used to control postoperative intraocular inflammation. Prednisolone acetate 1% and difluprednate 0.05% are commonly used but difluprednate has a risk of increasing intraocular pressure. The aim of the present study was to compare the changes in intraocular pressure using prednisolone acetate 1% and difluprednate butyrate acetate 0.05% after cataract surgery with frequent dosing. Materials and Methods: The nonrandomized clinical trial study was performed in the Department of Ophthalmology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, from June 2019 to June 2020. A total of 84 patients were selected and were divided into two cohorts, group A and group B. In each group, there were 42 patients. Result: Intraocular pressure was elevated in 2.4% of group A and 4.7% of group B on the 7th postoperative day. Increased IOP >6 mm Hg from baseline was seen in 2.4% of group A and 7.2% of group B. Statistically significant difference in intraocular pressure from baseline was seen in the first and second follow-up. No significant elevation was seen on the 45th day and the difference returned to normal. Conclusion: Intraocular pressure was significantly different from baseline on the 7th and 21st postoperative day. It returned to normal after 45 days. Both drugs can be used with frequent monitoring of intraocular pressure in the first week.