Abstract
Aim of the workTo compare the expression of serum interleukin 33 (IL33), a new member of the interleukin1 (IL-1) cytokine family, in rheumatoid arthritis (RA) versus osteoarthritis (OA) patients and to correlate it with clinical, laboratory and radiographic parameters.Subjects and methods20 RA and 20 primary knee OA patients. The levels of serum IL-33 were measured by enzyme-linked immunosorbent assay (ELISA) while anticyclic citrullinated peptide (Anti-CCP), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured by standard laboratory techniques. Plain x-ray of both hands and wrists were evaluated using the modified Larsen score 1995 (MLS) in RA patients. Knee OA grading was performed according to the Kellgren Lawrence classification. The correlation of IL-33 level with clinical, laboratory and radiological data of RA and OA was analyzed.ResultsSerum IL-33 level was significantly higher in RA than in OA patients (P< 0.001). This level was positively correlated with disease duration, clinical and laboratory markers of disease activity, impaired functional status and radiographic severity in RA while not in OA patients.ConclusionsThese findings support that IL-33 could have an essential proinflammatory role in the pathogenesis of RA and that IL-33 level may be a monitor of disease activity and severity. IL-33 may become therapeutic target for RA.
Highlights
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown etiology that primarily involves the joints but can cause multiple extra-articular manifestations
Serum Interleukin 33 (IL-33) levels were not correlated with demographic data in studied RA patients
There was a significant correlation between serum IL-33 levels and disease duration, morning stiffness, number of tender joints, number of swollen joints, Visual Analogue Scale of pain, DAS28 score, Modified Health Assessment Questionnaire, erythrocyte sedimentation rate (ESR) first hour, Study of IL-33 in RA versus OA patients Abd El-Aziz Farag et al 161
Summary
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown etiology that primarily involves the joints but can cause multiple extra-articular manifestations. RA is the most common autoimmune disease. It is characterized by synovitis and autoantibody formation. The hallmark feature of the disease is persistent symmetric polyarthritis that affects the hands, wrists and feet, almost all diarthrodial joints may become involved. Osteoarthritis (OA) is a common condition associated with pain and irreversible progressive joint damage that undermines the quality of life. This multifactorial disease is characterized by destruction of the joint cartilage, subchondral bone thickening and osteophyte formation [2]
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