Study of Inhibition Effect of Three Pyrimidine Derivatives on Growth of Human Epidermoid Larynx Carcinoma Cell Line (Hep-2) (In vitro)

Abstract

he present paper included a study of the inhibitory effect of three pyrimidine derivatives (6-amino 1,3dimethyl uracil (6-admu), 2'-deoxythmidine (dthy) and 6-(phenylazo)-cytidine (phazocyt)) in comparison with the medical compound (6-MP) as a standard anti cancer on the inhibition of the growth of cancer cell line of Hep-2 (Human epidermoid larynx carcinoma) In vitro. Results have shown significant differences of a probability level (p<0.001), compared with 6-MP compound of (phazocyt and 6-admu), while (dthy) compound did not show any significant differences at the same level of probability (p>0.001). When comparing the inhibitory effect of concentrations within the single compound, we notice significant differences of the probability level (p<0.001), starting from the first treatment (62.5mg/ml) of (dthy) and (phazocyt) compounds. (6-admu) compound showed a significant effect in the last treatment. Result have revealed that the two compounds (dthy, phazocyt) have greater effect in comparison with 6-MP compound within (125mg/ml) concentration. Also, values of lethal inhibition concentration of (IC50) and lethal concentration of 90% of cells (IC90) were extracted. It has been found that the best activity was for (dthy) compound.