Study of Influence on Ovarian Function by HIFU and Surgical Treatment for Uterine Fibroids

Abstract

Objective To explore the influence on ovarian function by HIFU, myomectomy, and hysterectomy for uterine fibroids. Methods From January 2008 to December 2010, 90 women with uterine fibroids were included in the study, and divided into high intensity focused ultrasound (HIFU)group(n=30), myomectomy group(n=30) and hysterectomy group(n=30) according to treatment method. Measure and compare the serum follicle-stimulating hormone (FSH), luteinizing hormone(LH)and estradiol hormone(E2) level changes at 6 months before and after treatment.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Futian People's Hospital of Shenzhen. Informed consent was obtained from each patient. There has no significant differences between ages, clinical symptom and clinical classification among three groups(P>0.05). Results No significant difference was found in hormone levels between preoperative and 6 months after treatment in HIFU group and myomectomy group. 6 months after hysterectomy, FSH, LH increased and E2 decreased which were significant differences compared to preoperative(P<0.05). There had significant differences of hormone level change between HIFU group and hysterectomy group in 6 months after treatment. Conclusions HIFU treatment for childbearing age women with uterine fibroids does not influence the ovarian function. Key words: high intensity focused ultrasound; uterine fibroids; surgery; ovarian function