Study of Inflammatory Biomarker (PARC/CCL 18) in Chronic Obstructive Pulmonary Disease and its Correlation with Disease Severity in South Indian Population

Abstract


 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Aim
 Our recent studies have shown that inflammatory biomarker (PARC/CCL 18) in chronic pulmonary disease and its correlation with disease severity in south Indian population. Chronic obstructive pulmonary disease (COPD) is a lung disease characterised by chronic obstruction of lung airways which is not entirely reversible. Pulmonary and activation-regulated chemokine ligand-18(PARC/CCL18) is a 7-kD protein that is constitutively expressed by monocytes/macrophages and dendritic cells and is secreted predominantly in the lung. It is a promising inflammatory marker in COPD.
 Material and Method
 This was a Descriptive study conducted in 130 male COPD patients. It was designed to assess the specific inflammatory marker and study their relationship with disease severity levels in male COPD patients.
 Results
 inflammatory biomarkers of Pulmonary and activation regulated chemokine ligand-18 levels were significantly (P<0.003) increased in very severe COPD patients when compared with mild, moderate and severe COPD patients.
 Conclusion
 From the present study, we conclude that in COPD specific biomarker serum PARC/CCL18 associated with disease severity