Abstract
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity and diabetes, and is characterized by insulin resistance (IR) Cytokines and adipocytokines (i.e. mediators mainly derived from adipose tissue) play a major role in the orchestration of inflammatory processes throughout the body. Aim and objectives To evaluate the relation between serum levels of IL-10 and NAFLD in Egyptian patients. Subjects and methods This study is A randomized case control cross sectional study, was carried out at Eldemrdash University Hospital, Internal medicine departments, on patients above 18 years old with Hepatic Steatosis Index (HSI) and NAFLD, duration of study about 6 months. Result There was high statistically significant difference between studied cases as regard IL-10. Conclusion High IL-10 levels limiting the effects of the inflammatory response that is, by counter regulating the effects of pro-inflammatory cytokine so that the protective function of IL-10 in steatotic liver relies on suppression of TNF-a production. Morbidly obese patients with increased age and elevated levels of LDL, fasting glucose, HOMA-IR, and TNF-a, in combination with low circulating levels of IL-10, seem to be at higher risk to develop severe-NAFLD and should be clinically monitored.
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