Abstract
In this paper, icaritin film was prepared by low-energy beam electron beam deposition (EBD). The material test showed that the structure and composition of icaritin were not changed after electron beam deposition. Then, the film was sliced and immersed in simulated body fluids, it can be seen that the film was released quickly in the first 7 days. With the extension of soaking time, the release rate gradually slowed down, and the release amount exceeded 90% in about 20 days. In vitro cytotoxicity test showed that the relative cell viability rate of the film was still 92.32±1.30% (p<0.05), indicating that the film possessed excellent cytocompatibility.
Highlights
Metal-based implant materials have excellent mechanical properties, machinability and favorable stability, which are often used in bone tissue engineering to repair or replace human bone tissue [1], accounting for about 70‒80% of the total implant materials [2]
The 1HNMR spectra of icaritin film and icaritin powder prepared by electron beam deposition (EBD) method were compared and analyzed
The results showed that icaritin still existed on the substrate surface after 7 days and 21 days immersion of simulated body fluids, and the characteristic peaks obtained by C1s fitting were the same as those obtained before immersion, which proved that the composition and structure of icaritin film could remain stable after immersion of simulated body fluids
Summary
Metal-based implant materials have excellent mechanical properties, machinability and favorable stability, which are often used in bone tissue engineering to repair or replace human bone tissue [1], accounting for about 70‒80% of the total implant materials [2]. [2, 5,6,7,8,9], and they are widely used implants medical metal materials These implants themselves lack the ability to form or induce osteogenesis. Before implant implantation, loading these medical metal materials for bone tissue engineering with highly effective bioactive factors can promote tissue healing, bone remodeling and bone repair around the scaffold [10].
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