Study of hyperthermia temperature of manganese-substituted cobalt nano ferrites prepared by chemical co-precipitation method for biomedical application

Abstract

Abstract The initiation of ferrite nanoparticles has changed the perception of nanotechnology in the biomedical field especially magnetic hyperthermia based application. Wet chemical co-precipitation method has been used to synthesize chitosan-coated Co1−xMnxFe2O4 (0.0 ≤ x ≤ 1.0, in the steps of 0.2) nano ferrites. From the XRD data, the lattice constant, ionic radii and bond lengths at tetrahedral sites and octahedral sites were estimated. The analysis revealed that the hoping lengths at tetrahedral and octahedral sites are increased with the addition of manganese content. The FESEM has shown that the ferrite nanoparticles are agglomerated in the powder sample. The magnetic characterization has been done by VSM. Heating of the nanoparticles is dependent on hysteresis loss that is related to the larger area of the hysteresis loop. In agreement with magnetization data, there shows a transition from ferromagnetic to paramagnetic behaviour revealed by Mossbauer spectra. From Mossbauer spectra, values of isomer shift, quadrupole splitting, and hyperfine field have been measured. Hydrodynamic diameter and polydispersity index (PDI) of all coated samples have been found in the limits that the samples can be used for biomedical applications. Hyperthermia temperatures of all coated ferrite samples have been measured. From the steep slope of time dependence temperature graph, the value of specific loss power (SLP) has been calculated and found that the SLP value is highest for Co0.8Mn0.2Fe2O4.