Abstract
BackgroundCystic hydatid disease is still an important health problem in European Mediterranean areas. In spite of being traditionally considered as a “benign” pathology, cystic echinococcosis is an important cause of morbidity in these areas. Nevertheless, there are few analyses of mortality attributed to human hydatidosis.ObjectiveTo describe the epidemiology, the mortality rate and the causes of mortality due to E. granulosus infection in an endemic area.MethodologyA retrospective study followed up over a period of 14 years (1998–2011).Principal FindingsOf the 567 patients diagnosed with hydatid disease over the period 1998–2011, eleven deaths directly related to hydatid disease complications were recorded. Ten patients (90.9%) died due to infectious complications and the remaining one (9.1%) died due to mechanical complications after a massive hemoptysis. We registered a case fatality rate of 1.94% and a mortality rate of 3.1 per 100.000 inhabitants.ConclusionsHydatidosis is still a frequent parasitic disease that causes a considerable mortality. The main causes of mortality in patients with hydatidosis are complications related to the rupture of CE cysts with supurative collangitis. Therefore, an expectant management can be dangerous and it must be only employed in well-selected patients.
Highlights
The main causes of mortality in patients with hydatidosis are complications related to the rupture of cystic echinococcosis (CE) cysts with supurative collangitis
Human cystic echinococcosis (CE) is a zoonotic infection caused by Echinococcus granulosus, and it causes above 1.009 DALYs and annual cost of US 763 million dollars worldwide, brining its socioeconomic impact higher than Chagas or Hansen’s disease [1]
The aim of the present study is to describe the mortality epidemiology, the clinical settings and the treatment applied to patients who died due to hydatidosis our area
Summary
Human cystic echinococcosis (CE) is a zoonotic infection caused by Echinococcus granulosus, and it causes above 1.009 DALYs (disability-adjusted life year) and annual cost of US 763 million dollars worldwide, brining its socioeconomic impact higher than Chagas or Hansen’s disease [1]. Cystic echinococcosis (CE) is usually asymptomatic and it has traditionally been considered a ‘‘benign’’ pathology. Rupture of the hydatid cyst and compression of pericystic structures are the most frequent complications related to CE. Hypersensitivity reactions caused by circulating immune complexes and the activation of complement pathway which give rise to glomerulonephritis and anaphylactoid reactions are other complications frequently associated with hydatidosis disease [6,7]. Despite the available therapeutic alternatives, there is still a certain mortality rate directly related to hydatid cystic complications [9]. Cystic hydatid disease is still an important health problem in European Mediterranean areas. In spite of being traditionally considered as a ‘‘benign’’ pathology, cystic echinococcosis is an important cause of morbidity in these areas. There are few analyses of mortality attributed to human hydatidosis
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