Study of hemodynamic and cardiac function changes in pediatric liver transplantation from living related donors

Abstract

Objective To investigate the changes of hemodynamics and cardiac function in pediatric living donor liver transplantation (LDLT). Methods 50 cases of pediatric living donor liver transplantation in our hospital from January 2016 to January 2017 were collected. The hemodynamics was monitored by Mostcare with the radial artery. Acquisition of heart rate (HR), mean arterial pressure (MAP), peripheral vascular resistance index (SVR/SVRI), stroke volume / stroke index (SV/SVI), cardiac output (CO/CI), cardiac index / stroke volume variability (SVV), dp/dtmax (cardiac contractility), cardiac cycle efficiency (CCE) at the moment of the start of operation(T0), before occlusion of the inferior vena cava (T1), immediately after occlusion of the inferior vena cava (T2), anhepatic phase 30 min (T3), immediately after reperfusion(T4), neohepatic phase 5 min (T5), 30 min (T6) and 60 min (T7). Results There were no significantly hemodynamic fluctuations before occlusion of the portal vein. At T3, the increased of MAP, CI, SVRI (T3 vs T0, P<0.05), while CCE decreased significantly (T3 vs T0, P<0.05); MAP, SVRI, lower HR, CI and dp/dtmax have different degrees of liver T4, but the change was not significant. SVV fluctuated in the anhepatic phase at 11%~15%, maintained in the new liver stage at 12%~15%, but fluctuated slightly. Conclusion Mostcare can be used to monitor the hemodynamic and cardiac function changes in pediatric living donor liver transplantation, but the reasons for the change of the monitoring indicators and the significance of guiding the perioperative treatment need to be further studied. Key words: Pediatric; Liver transplantation; Hemodynamic; Cardiac output