STUDY OF HEMATOLOGICAL MANIFESTATIONS IN COVID-19 INFECTED PATIENTS AND THEIR OUTCOME-OBSERVATIONAL RETROSPECTIVE LONGITUDANAL STUDY

Abstract

Background COVID-19 is an ongoing global pandemic. Changes in haematological characteristics in patients with COVID-19 are emerging as important features of the disease. We aimed to explore the haematological characteristics and related risk outcome in patients with COVID-19. 1.To stud Objectives: y haematological manifestations in patients withCOVID-19 infected patients. 2.To study the severity of covid 19 infection with respect to thrombocytopenia. Observational retrospective longitudinal study done on patients admitted to Materials and methods: general medicine department of S Nijalingappa Medical College and HSK hospital, Bagalkot, Karnataka. Patients with COVID-19 Pneumonia are included in the study after meeting inclusion and exclusion criteria Data from Results: 96 patients admitted to hospital with conrmed COVID-19 were analysed in our study .The patients with severe and critical disease were older than those with moderate disease. Women had more severe disease than men. Of the haematological parameters neutrophil count, lymphocyte count, neutrophil to lymphocyte ratio(NLN ) and platelet count were signicantly different across all comparisons. Counts of platelets were signicantly lower in patients with severe disease.(p<0·0001). In the present study majority of the patients have NLN ratio >3.5(59.4%).Death have occurred more in patients with >3.5 NLN ratio i,e; 52% in patients with NLN ratio >3.5. In the present study most of the patients have platelets between 1.5lakh to 2 lakh.But the mortality is more in between 50,000-1,00,000 platelet i,e; 32.4%. The study of haematolog Conclusion: ical parameters mainly thrombocytopenia and NLN ratio helps in assessing the severity of disease and the outcome. An early diagnosis and recognition of severe COVID-19 infection with these parameters helps in preventing future mortality and helps in the proper management of the disease.