Abstract
Objective: To study some hematological parameters in patients with complicated severe malaria and their relations to clinical outcome. Materials and Methods: This was a cross sectional observational study, including 100 patients from a tertiary care centre in Ghaziabad patients who were diagnosed to have malaria by peripheral smear examination (both thick and thin smear) or Malaria Rapid Antigen. Blood sample for haematological and coagulation study were taken. Results: Out of 100 patients 62 patients had Hb % less than 10 gm percentage in which 14 patients had Hb < 6> of the total patients. Packed cell volume was decreased in about 86% of the patients. ESR increase was seen in 73% of the patient. Thrombocytopenia was observed in 63% of the patients and 25% of the patients with mixed infection had severe thrombocytopenia. PT and APTT was increased in 22% and 14% of the total cases. Bleeding time was increased in 5% of the total case and no any patients with vivax malaria had increased bleeding time. Mixed infection shows as falciparum malaria. Sever anemia, thrombocytopenia, increase BT, PT and APTT associated to severity and complication of malaria. Conclusion: This study concluded that hematological changes are common complications encountered in severe malaria, but they are not related to the clinical outcome. Keywords: Severe malaria, Thrombocytopenia, Prothrombin time, APTT.
Highlights
Malaria is a common protozoal disease transmitted by the bite of infected female Anopheles mosquitoes
It was found to be increased in 14.28% of patients with falciparum malaria. 7.5% of the vivax malaria patients had elevated Activated partial thromboplastin time (aPTT) and 75% of the mixed infection patients had elevated aPTT
The percentage of patients with PCV
Summary
Malaria is a common protozoal disease transmitted by the bite of infected female Anopheles mosquitoes. It is prevalent in 108 countries containing 3 billion peoples and causes nearly 1 million deaths each year.. India has taken steps to control malaria such as National Malaria Control Programme in 1953 After this government came out with National Malaria Eradication Programme (NMEP) in 1958. Hematological abnormalities are considered a hallmark of malaria, bearing an impact on final outcome and representing indices of prognostic and follow up value. These include severe anemia, coagulation disturbances, leucocyte numerical or functional changes and spleen involvement. Mitra and Singh / Santosh University Journal of Health Sciences 2020;6(1):
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