Study of golgi protein-7 levels associated cirrhosis in patients with infections hepatitis B virus

Abstract

Background/Aims: Infection with the hepatitis B virus (HBV) is a major health concern that can lead to liver failure. The hepatitis B virus (HBV) infects humans in both acute and chronic forms. The transmission of this infectious illness is caused by several risk factors. The goal of this study was to look at the epidemiology and risk factors of HBV infection. HBV infection is associated with cirrhosis and/or hepatocellular cancer (HCC). Golgi protein 73(GP73) in human serum is a useful biomarker in the evaluation of hepatic fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) by hepatitis B virus (HBV). The purpose of this study was to evaluate the serum GP73 level's ability to predict HBV infection caused by cirrhosis and/or HCC. Methods: In serum samples, GP73 levels were determined using an enzyme-linked immunosorbent assay (ELISA). This study looked at the underlying function of HBV-induced GP73 in controlling cirrhosis and/or HCC development. ELISA was used to assess hepatitis B surface Antigen (HBsAg) and GP73 expression in HBV-related to cirrhosis and/or hepatocellular cancer (HCC). Results: This study included a total of 35 patients with HBsAg by ELISA technique and 18 persons as control group negative to (HBsAg, anti-HBc-Ab, anti-HCV-Ab, HIV).