Abstract
Vascular endothelial growth factor (VEGF) regulates endothelial cell proliferation, migration and differentiation. VEGF plays a critical role in angiogenesis during placenta formation. We investigated whether VEGF gene polymorphisms are associated with recurrent pregnancy loss. One hundred women with recurrent abortion and 100 control women with live-born children were recruited from healthy Egyptian women. VEGF gene polymorphisms were assessed with PCR-RFLP analysis of DNA samples obtained from peripheral blood. DNA fragments were investigated by using appropriate primers. SNP scanning was performed using MnII, BgIII, BsfmI, and NIaII restriction enzymes for 1154 G/A, 2578 C/A, 634 C/G, and 936 C/T polymorphisms, respectively. Recurrent abortion among Egyptian women was strongly associated with the mutations related to VEGF gene polymorphism. Interestingly, VEGF 1154 G/A, 2578 C/A and 634 C/G mutation frequencies were significantly higher different between the controls and women with recurrent abortion. However, the 936 C/T was not significantly in women with recurrent abortion.
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